J Korean Rheum Assoc.  1999 Mar;6(1):75-78.

A Case of Propylthiouracil-Induced Lupus

• Lee J
• Yoo B
• Lim YJ
• Kim SH
• Lim M
• Cho YS
• Shong YK
• Moon HB

Abstract

Propylthiouracil(PTU) is one of lupus-inducing drugs, though rarely reported. We report a case of PTU-induced lupus, with the review of of previous literatures. Lupus-like symptoms in a 28year-old female patient, who had been suffering from relapsed Graves' disease, were presented during PTU therapy. The results of antinuclear antibody and anti-histone antibody were positive. After symptomatic reatment and discontinuation of PTU, all of the symptoms and the abnormalities in laboratory tests disappeared, which suggested drug-induced lupus.

Keyword

Graves' disease; Drug-induced lupus; Propylthiouracil

MeSH Terms

Antibodies, Antinuclear
Female
Graves Disease
Humans
Propylthiouracil
Antibodies, Antinuclear
Propylthiouracil