Korean J Dermatol.  2006 Apr;44(4):467-469.

A Case of Propylthiouracil-induced Lupus Erythematosus

• Park CO
• Goo J
• Ahn SK

Abstract

A 14-year-old girl had a history of Graves' disease and received propylthiouracil (PTU) treatment for 2 years before admission to our hospital. She developed skin rash over her, whole body 1 month before admission, and laboratory examination revealed pancytopenia. Positive antinuclear antibodies, antihistone antibodies and reduced complement levels were noted, although anti-double-stranded DNA and anti-Sm antibodies were negative. A biopsy specimen revealed mild epidermal atrophy and peri-adnexal lymphoid cell infiltration. Linear deposition of IgM along the basement membrane zone was noted by direct immunofluorescence array. After discontinuation of PTU and steroid treatment, eruptions and pancytopenia improved, suggesting drug-induced lupus erythematosus.

Keyword

Drug-induced lupus erythemtosus; Graves' disease; Propylthiouracil

MeSH Terms

Adolescent
Antibodies
Antibodies, Antinuclear
Atrophy
Basement Membrane
Biopsy
Complement System Proteins
DNA
Exanthema
Female
Fluorescent Antibody Technique, Direct
Graves Disease
Humans
Immunoglobulin M
Lymphocytes
Pancytopenia
Propylthiouracil
Antibodies
Antibodies, Antinuclear
Complement System Proteins
DNA
Immunoglobulin M
Propylthiouracil