Korean J Dermatol.  2005 Apr;43(4):496-500.

A Case of Propylthiouracil-induced Lupus Erythematosus Accompanied by Antineutrophil Cytoplasmic Antibody-positive Vasculitis

• Kim JW
• Kim JS

Abstract

Propylthiouracil (PTU) as a drug for hyperthyroidism is known to be associated with drug-induced lupus erythematosus (LE) and antineutrophil cytoplasmic antibody (ANCA)-positive vascultis. A 29-year-old woman who had been receiving PTU for 12 months developed spiking fever, arthralgia and multiple purpuric skin lesions. Perinuclear ANCA (p-ANCA) with antimyeloperoxidase activity, antinuclear antibody and antihistone antibody were positive. Her condition improved after the withdrawal of PTU. The pertinent evaluation for this case established PTU-induced LE accompanied by ANCA-positive vasculitis. Although PTU-induced LE or ANCA-positive hypersensitivity vasculitis by PTU have been frequently reported in the literature, it is extremely rare that these two diseases have occurred simultaneously due to PTU, as in this case.

Keyword

Propylthiouracil; Lupus erythematosus; Antineutrophil cytoplasmic antibody; Vasculitis

MeSH Terms

Adult
Antibodies, Antineutrophil Cytoplasmic
Antibodies, Antinuclear
Arthralgia
Cytoplasm*
Female
Fever
Humans
Hyperthyroidism
Propylthiouracil
Skin
Vasculitis*
Vasculitis, Leukocytoclastic, Cutaneous
Antibodies, Antineutrophil Cytoplasmic
Antibodies, Antinuclear
Propylthiouracil