Ann Dermatol.
2010 Feb;22(1):48-50. 10.5021/ad.2010.22.1.48.
A Case of p-ANCA-Positive Propylthiouracil-Induced Pyoderma Gangrenosum
- Affiliations
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- 1Department of Dermatology, Maryknoll Medical Center, Busan, Korea. drj715@naver.com
- 2Department of Dermatology, College of Medicine, Inje University, Busan, Korea.
- KMID: 2172036
- DOI: http://doi.org/10.5021/ad.2010.22.1.48
Abstract
- Propylthiouracil is a common medication used in patients with hyperthyroidism; it can cause perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) in some patients with Graves' disease. This antibody has been associated with various forms of vasculitis and neutrophilic dermatosis. Herein, we report a patient who presented with cutaneous manifestations of pyoderma gangrenosum with simultaneous development of p-ANCAs during PTU therapy for Graves' disease.
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