J Korean Soc Emerg Med.  1997 Mar;8(1):9-16.

EFFECTS OF BRONCHODILATOR INHALATION ON LUNG MECHANICS IN ADULT RESPIATORY DISTRESS SYNDROME: EXPERIMENTAL STUDY

• Baek KJ
• Kim JS

Abstract

The acute respiratory distress syndrome (ARDS) is a disorder of diffuse lung injury secondary to a wide variety of clinical insults including sepsis. It is manifested by impaired oxygenation, pulmonary edema, decreased static and dynamic compliance of lung, and increased airway resistance. Reduced lung compliance together with increased airway resistance is a hallmark of the syndrome and has generally been considered as the primary abnormality of lung mechanics. The study was designed to reproduce an ARDS condition in an animal model with acute lung injury and to determine whether these changes are reversed by inhalation of aerosolized bronchodilator such as salbutamol or nicorandil. Six adult mongrel dogs were exposed to intravenous oleic acid (0.08 ml/kg) mixed into a same amount of pure enthanol. We defined a condition of PaO2 less than 60 mmHg in FiO2 0.6 as an acute diffuse lung injury. Lung mechanics were deteriorated after oleic acid injection, from 27.33+/-2.73 to 17.50+/-.47 cmH2O/l/sec in compliance and from 14.55+/-.46 to 26.33+/-.02 ml/cmH2O in airway resistance. Salbutamol or Nicorandil inhalation significantly improved lung compliance to 30.57+/-11.30 or 36.33+/-.00 cmH2O/l/sec and airway resistance to 16.77+/-.47 or 19.55+/-.45 ml/cmH2O. From above data, we carefully concluded that compromized lung mechanics in adult respiratory distress syndrome could be effectively managed by inhalation of aerolized bronchodilator.

MeSH Terms

Acute Lung Injury
Adult*
Airway Resistance
Albuterol
Animals
Compliance
Dogs
Humans
Inhalation*
Lung Compliance
Lung Injury
Lung*
Mechanics*
Models, Animal
Nicorandil
Oleic Acid
Oxygen
Pulmonary Edema
Respiratory Distress Syndrome, Adult
Sepsis
Albuterol
Nicorandil
Oleic Acid
Oxygen