Korean J Pathol.  2007 Oct;41(5):358-361.

Progressive Multifocal Leukoencephalopathy in the Immunocompromised Patients - 3 Cases Report

• Shim MK
• Kim JH
• Park CS
• Kim HS
• Choi YD
• Lee MC

Abstract

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease resulting from infection of oligodendrocytes with JC virus. PML was a rare disease, but nowadays not uncommon as AIDS prevailed. Histopathologic features of the affected lesion shows infiltrations of foamy macrophages and hyperchromatic, pleomorphic, reactive astrocytes that may raise the suspicion of a brain tumor. We recently met with 3 cases of PML. Two of the patients had AIDS and the other had been treated for lymphoma. All cases were diagnosed by histopathologic examination in stereotactic brain biopsies.

Keyword

Leukoencephalopathy, progressive multifocal; JC virus; Acquired immunodeficiency syndrome; Lymphoma; Biopsy

MeSH Terms

Acquired Immunodeficiency Syndrome
Astrocytes
Biopsy
Brain
Brain Neoplasms
Demyelinating Diseases
Humans
Immunocompromised Host*
JC Virus
Leukoencephalopathy, Progressive Multifocal*
Lymphoma
Macrophages
Oligodendroglia
Rare Diseases