Tuberc Respir Dis.  2007 Mar;62(3):237-240. 10.4046/trd.2007.62.3.237.

A Case of Pulmonary Choriocarcinoma

• Park S
• Yang WI
• Moon JA
• Byun MK
• Chung WY
• Choi SB
• Chung JH
• Kang SM
• Park MS
• Kim YS
• Chang J
• Cho NH
• Cho SH
• Kim SK
• Kim SK

• KMID: 1518471
• DOI: http://doi.org/10.4046/trd.2007.62.3.237

Abstract

Pulmonary choriocarcinoma is a very rare tumor in men. Herrein, the case of a pulmonary choriocarcinoma in 39-year-old man, and whether it had a primary nature, is reported. He denied any prior medical illness, but was admitted to our hospital with a history of a cough, and progressive dyspnea and hemoptysis 2 and 1 week duration, respectively. Chest radiographs on admission revealed a huge lung mass, 10 cm in diameter, in the left upper lung field, with left pleural effusion. Although biopsies using several diagnostic methods for the pathological confirmation were attempted, the pathology was not confirmed. Finally, the patient died after 2 months of regression. An autopsy of the lung was then performed.

Keyword

Choriocarcinoma; Lung; Men

MeSH Terms

Adult
Autopsy
Biopsy
Choriocarcinoma*
Cough
Dyspnea
Female
Hemoptysis
Humans
Lung
Male
Pathology
Pleural Effusion
Pregnancy
Radiography, Thoracic

Figure

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  Figure 1 Chest PA, Huge lung mass in left upper lobe

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  Figure 2 Chest CT, A 10×6 cm sized large mass is noted on the left upper lobe paramediastinal area. The mass contiguously invasdes mediastinum and contacting the aortic arch. Another 4.4×3.4 cm mass is noted at the left lower lobe medial subpleural area.

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  Figure 3-1 Gross pathology, multiple lung masses are scattered in entire lung

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  Figure 3-2 Fenestrated sheets of cytotrophoblast mixed with numerous syncytiotrophoblasts and extensive hemorrhage and necrosis (×12, H & E stains)

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  Figure 3-3 Cytotrophoblastic cells situated centrally and surrounded by irregular collection of syncytiotrophoblastic cells (×200, H & E stains)

Reference

1. Chen F, Tatsumi A, Numoto S. Combined choriocarcinoma and adenocarcinoma of the lung occurring in a man: case report and review of the literature. Cancer. 2001. 91:123–129.

2. Arslanian A, Pischedda F, Filosso PL, Di Marzio P, Oliaro A, Fraire F, et al. Primary choriocarcinoma of the lung. J Thorac Cardiovasc Surg. 2003. 125:193–196.

3. Rossi G, Valli R, Rivasi F, Longo L. Does primary pulmonary choriocarcinoma really exist? Chest. 2003. 123:313.

4. Ikura Y, Inoue T, Tsukuda H, Yamamoto T, Ueda M, Kobayashi Y. Primary choriocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung: are they independent entities? Histopathology. 2000. 36:17–25.

5. Rhee YK, Kim JH, Kim WH, Ha CY, You KH, Jang DS. Primary choriocarcinoma of the lung. Kor J Intern Med. 1987. 2:269–273.

6. Ko KS, Bae IH, Cho IS, Rhee KJ, Kim SY. A case of primary choriocarcinoma of the lung. Kor J Med. 1990. 39:569–575.

7. Chang SW, Park JO, Lee KY, Lee WA, Ryu JW, Park SS, et al. Rapidly progressed primary choriocarcinoma of the lung. Kor J Thorac Cardiovasc Surg. 2004. 37:805–808.

8. Yamamoto S, Tanaka H, Takeo H, Yasuda K, Mastukuma S. Primary pulmonary choriocarcinoma combined with adenocarcinoma. Pathol Int. 2006. 56:402–407.

9. Tsai JR, Chong IW, Hung JY, Tsai KB. Use of urine pregnancy test for rapid diagnosis of primary pulmonary choriocarcinoma in a man. Chest. 2002. 121:996–998.

10. Ino K, Mitsui T, Nomura S, Kikkawa F, Mizutani S. Complete remission of gestational choriocarcinoma with choroidal metastasis treated with systemic chemotherapy alone: case report and review of literature. Gynecol Oncol. 2001. 83:601–604.

11. Okur E, Halezeroglu S, Somay A, Atasalihi A. Unusual intrathoracic location of a primary germ cell tumour. Eur J Cardiothorac Surg. 2002. 22:651–653.

12. Balagopal P, Pandey M, Chandramohan K, Somanathan T, Kumar A. Unusual presentation of choriocarcinoma. World J Surg Oncol. 2003. 1:4.

13. Shintaku M, Hwang MH, Amitani R. Primary choriocarcinoma of the lung manifesting as diffuse alveolar hemorrhage. Arch Pathol Lab Med. 2006. 130:540–543.