Korean J Hematol.  2003 Nov;38(4):270-273.

Resolution of Chronic Idiopathic Thrombocytopenic Purpura after Eradication of Helicobacter pylori: A Case Report

• Choi DS
• Seo YT
• Choi SH
• Kim HJ
• Kim BS

Abstract

Helicobacter pylori (H. pylori) has been recognized as a main cause of gastritis and most cases of peptic ulcer, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. An immunological response to H. pylori infection has been suggested to play a major role in determining gastroduodenal damage through the production of cytokines and the autoantibody against gastric epithelial cell. H. pylori has been implicated in the pathogenesis of some autoimmune disease, such as Sjogren disease, Henoch-Schnlein purpura, rheumatoid arthritis, autoimmune thyroid disease, and idiopathic thrombocytopenic purpura (ITP). Serveral studies recently showed a high prevalence of H. pylori infection in patients with ITP and reported a platelet recovery after bacterial eradication therapy. We report a case of a 54-year-old man with chronic ITP who was resolved after eradication of H. pylori.

Keyword

Idiopathic thrombocytopenic purpura (ITP); Helicobacter pylori

MeSH Terms

Adenocarcinoma
Arthritis
Autoimmune Diseases
Blood Platelets
Cytokines
Epithelial Cells
Gastritis
Helicobacter pylori*
Helicobacter*
Humans
Lymphoma, B-Cell, Marginal Zone
Middle Aged
Peptic Ulcer
Prevalence
Purpura, Schoenlein-Henoch
Purpura, Thrombocytopenic, Idiopathic*
Thyroid Diseases
Cytokines