Korean J Phys Anthropol.  2006 Mar;19(1):37-48.

Differential Expression of System L Amino Acid Transporters in Wound Healing Process of Rat Skin

• Jeong MJ
• Kim CH
• Choi BD
• Jeong SJ
• Park JC
• Kim HJ
• Park KJ
• Kim DK

Abstract

The continuous growth and proliferation of cells are essential for the wound healing process, and the amino acid transporters plays an important role in the continuous growing and proliferating cells. Among the amino acid transport systems, the amino acid transport system L, which is a Na+/-independent neutral amino acid transport system, is a major route for providing living cells including tumor cells with neutral amino acids including several essential amino acids. In the present study, to elucidate the role of amino acid transport system L in the wound healing process, we investigated the expression pattern of LAT1 and LAT2 in the healing process after inflicting the wound on skin of rat. The expression of LAT1 was increased at 12 hours after inflicting the wound and was similar to the control group getting closer to 7 days. The expression of LAT2 was increased at 1 day and 3 days after inflicting the wound and was similar to the control group getting closer to 7 days. These results suggest that the LAT1 and LAT2 play important roles at the early stage and at the middle stage getting closer to normal skin in the wound healing process after inflicting the wound, respectively.

Keyword

Wound healing; System L amino acid transporters; Nutrition to cells; Epithelial tissue

MeSH Terms

Amino Acid Transport System L
Amino Acid Transport Systems*
Amino Acids, Essential
Amino Acids, Neutral
Animals
Rats*
Skin*
Wound Healing*
Wounds and Injuries*
Amino Acid Transport System L
Amino Acid Transport Systems
Amino Acids, Essential
Amino Acids, Neutral