J Korean Endocr Soc.  2007 Jun;22(3):220-224. 10.3803/jkes.2007.22.3.220.

A Case of Graves' Disease Associated with Systemic Sclerosis

• Lee YJ
• Kim MK
• Lim DJ
• Hur KH
• Baek KH
• Kang MI
• Cho CS
• Lee KW
• Park GS

• KMID: 1512035
• DOI: http://doi.org/10.3803/jkes.2007.22.3.220

Abstract

Systemic sclerosis is associated with a broad spectrum of autoimmune thyroid diseases. The association between systemic scleroderma and hypothyroidism is well established. However, there have been very few reports concerning the association between hyperthyroidism and systemic scleroderma. We experienced a patient with Graves' disease who presented with muscle weakness and the patient was finally diagnosed with systemic sclerosis via pathological examination of the muscle. We describe here a rare case of systemic sclerosis associated with Graves` disease.

Keyword

Graves' disease; Systemic sclerosis; Total thyroidectomy

MeSH Terms

Graves Disease*
Humans
Hyperthyroidism
Hypothyroidism
Muscle Weakness
Scleroderma, Systemic*
Thyroid Diseases

Figure

• 

  Fig. 1 99mTc thyroid scan. 99mTc thyroid scan shows diffuse enlargement of both thyroid gland and uneven uptake of 99mTc. There are multinodular goiter. There are variable sized cold areas in both thyroid lobe.

• 

  Fig. 2 Histology of thyroid. A, There is nodular Hashimoto's thyroiditis (H&E, ×40); B, There are diffuse hyperplastic follicles of background Graves' disease (H&E, ×100).

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  Fig. 3 Histology of skin biopsy. A, There are hyalinized collagen bundles with atrophic adnexa and perivascular lymphoid infiltration (H&E, ×40); B, There is hyalinized intermysial fibrous tissue (H&E, ×100).

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