Korean J Otorhinolaryngol-Head Neck Surg.  2014 Feb;57(2):124-127. 10.3342/kjorl-hns.2014.57.2.124.

New Treatment for Isolated Invasive Aspergillosis of Sphenoid Sinus in Immunocompetent Subjects: Sphenoid Nasalization Combined with Voriconazole

• Kim DK
• Heo ST
• Kim SH
• Kim DW

• KMID: 1508316
• DOI: http://doi.org/10.3342/kjorl-hns.2014.57.2.124

Abstract

Isolated invasive fungal sinusitis of sphenoid sinus in a healthy immunocompetent person is extremely rare. Classical treatment of invasive fungal sinusitis is wide sphenoidotomy and surgical debridement combined with antifungal agents, mostly amphotericin B. We describe a case of a 72-year-old immunocompetent woman who presented with deep-seated orbital pain and was diagnosed as isolated invasive aspergillosis in sphenoid sinus invading orbital apex and cavernous sinus. This case was treated successfully with a new combination treatment of sphenoid nasalization and voriconazole, a new antifungal agent. There was no evidence of postoperative recurrence and side effects during the usage of voriconazole.

Keyword

Invasive aspergillosis; Invasive fungal sinusitis; Sphenoid sinus; Sphenoidotomy; Voriconazole

MeSH Terms

Aged
Amphotericin B
Antifungal Agents
Aspergillosis*
Cavernous Sinus
Debridement
Female
Humans
Orbit
Recurrence
Sinusitis
Sphenoid Sinus*
Amphotericin B
Antifungal Agents