Immune Netw.  2013 Oct;13(5):184-193. 10.4110/in.2013.13.5.184.

Emerging Co-signaling Networks in T Cell Immune Regulation

• Jung K
• Choi I

• KMID: 1493612
• DOI: http://doi.org/10.4110/in.2013.13.5.184

Abstract

Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell receptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the understanding of underlying mechanisms of the immune modulation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of autoimmune diseases and cancers. In this review, we briefly describe the characteristics of well-known B7 co-signaling family members regarding the expression, functions and therapeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.

Keyword

Co-signaling molecule; B7 family; Co-stimulation; Co-inhibition

MeSH Terms

Antigen-Presenting Cells
Autoimmune Diseases
Humans
Ligands
Membrane Glycoproteins
Receptors, Antigen, T-Cell
T-Lymphocytes
Ligands
Membrane Glycoproteins
Receptors, Antigen, T-Cell

Figure

• 

  Figure 1 Schematic diagram of B7 co-signaling family network.

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