Clin Exp Reprod Med.  2013 Jun;40(2):76-82. 10.5653/cerm.2013.40.2.76.

Blood glucose levels, insulin concentrations, and insulin resistance in healthy women and women with premenstrual syndrome: a comparative study

• Zarei S
• Mosalanejad L
• Ghobadifar MA

• KMID: 1493213
• DOI: http://doi.org/10.5653/cerm.2013.40.2.76

Abstract

OBJECTIVE
To compare the blood glucose levels, insulin concentrations, and insulin resistance during the two phases of the menstrual cycle between healthy women and patients with premenstrual syndrome (PMS).
METHODS
From January of 2011 to the August of 2012, a descriptive cross-sectional study was performed among students in the School of Medicine of Jahrom University of Medical Sciences. We included 30 students with the most severe symptoms of PMS and 30 age frequency-matched healthy controls. We analyzed the serum concentrations of glucose, insulin, and insulin resistance by using the glucose oxidase method, radioimmunometric assay, and homeostasis model assessment of insulin resistance equation, respectively.
RESULTS
No significant differences between the demographic data of the control and PMS groups were observed. The mean concentrations of glucose of the two study groups were significantly different during the follicular and luteal phases (p=0.011 vs. p<0.0001, respectively). The amounts of homeostasis model assessment of insulin resistance of the two study groups were significantly different in the luteal phase (p=0.0005).
CONCLUSION
The level of blood glucose and insulin resistance was lower during the two phases of the menstrual cycle of the PMS group than that of the controls.

Keyword

Glucose; Insulin; Insulin resistance; Menstrual cycle; Premenstrual syndrome

MeSH Terms

Blood Glucose
Cross-Sectional Studies
Female
Glucose
Glucose Oxidase
Homeostasis
Humans
Insulin
Insulin Resistance
Luteal Phase
Menstrual Cycle
Premenstrual Syndrome
Blood Glucose
Glucose
Glucose Oxidase
Insulin