Mycobiology.  2008 Sep;36(3):195-197. 10.4489/MYCO.2008.36.3.195.

Screening and Optimal Extraction of a New Antidementia beta-Secretase Inhibitor-Containing Mushroom

• Seo DS
• Lee EN
• Seo GS
• Lee JS

• KMID: 1487344
• DOI: http://doi.org/10.4489/MYCO.2008.36.3.195

Abstract

To produce a potent antidementia beta-secretase inhibitor from a mushroom, the beta-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40degrees C for 24 h.

Keyword

Antidementia; BACE1; beta-Secretase inhibitor; Lentinula edodes

MeSH Terms

Agaricales
Amyloid Precursor Protein Secretases
Fruit
Mass Screening
Methanol
Shiitake Mushrooms
Amyloid Precursor Protein Secretases
Methanol