- Molecular Genetic Aspects of Alzheimer's Disease
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Han SH
- KMID: 2416590
- J Korean Med Assoc.
- 2002 Apr;45(4):378-384.
- doi: 10.5124/jkma.2002.45.4.378
Alzheimer's disease (AD), the cause of one of the most common types of dementia, is pathologically characterized by cholinergic deficits, extracellular amyloid deposit, intraneuronal neurofibrillary tangles, gliosis, and neuronal and... -
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- A Newer Therapeutic Strategies For Alzheimer's Disease
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Han SH
- KMID: 2185998
- J Korean Neurol Assoc.
- 2001 Nov;19(6):559-565.
Alzheimer's disease (AD) is characterized pathologically by cholinergic deficits, extracelluar amyloid deposit, intra-neuronal neurofibrillary tangles, gliosis and neuronal and synaptic loss. The primary therapeutic approach has been cholinergic augumentation by... -
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- Mercury induced the Accumulation of Amyloid Beta (Abeta) in PC12 Cells: The Role of Production and Degradation of Abeta
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Song JW, Choi BS
- KMID: 2317841
- Toxicol Res.
- 2013 Dec;29(4):235-240.
Extracellular accumulation of amyloid beta protein (Abeta) plays a central role in Alzheimer's disease (AD). Some metals, such as copper, lead, and aluminum can affect the Abeta accumulation in the... -
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- Screening and Optimal Extraction of a New Antidementia beta-Secretase Inhibitor-Containing Mushroom
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Seo DS, Lee EN, Seo GS, Lee JS
- KMID: 1487344
- Mycobiology.
- 2008 Sep;36(3):195-197.
- doi: 10.4489/MYCO.2008.36.3.195
To produce a potent antidementia beta-secretase inhibitor from a mushroom, the beta-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity... -
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- Immunohistochemical Study on GTP-binding Rab6 Expression in the Hippocampal Cortices of the Alzheimer Brain
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Cheon YH, Kang YJ, Lee JH, Pyo JS, Baik TK
- KMID: 2092863
- Korean J Anat.
- 2005 Oct;38(5):451-459.
The ras-related GTP binding protein, rab6, is located in late Golgi compartment. Modulation of beta-and gamma-secretase activity may lead to production of beta-amyloid fragments that are ultimately deposited in senile... -
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- Effect of Ischemic Neuronal Insults on Amyloid Precursor Protein Processing
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Lee PH, Hwang EM, Mook-Jung , Huh K, Choi IS
- KMID: 2343147
- J Korean Neurol Assoc.
- 2005 Apr;23(2):241-248.
BACKGROUND: In spite of the different pathogenesis and exclusive respect in the diagnosis of Alzheimer's disease (AD) and vascular dementia (VaD), recent epidemiological and pathological studies indicates that ischemic stroke... -
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- Alteration of NOTCH1 in T-cell Acute Lymphoblastic Leukemia and Development of Target Therapeutic Agent
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Rho JH, Jeon IS
- KMID: 2279833
- Clin Pediatr Hematol Oncol.
- 2014 Apr;21(1):1-8.
T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 10-15% of entire ALL in children. The outcome of T-ALL has been improved through the intensified therapeutic strategy, however, it is still... -
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- Altered expression of gamma-secretase components in animal model of major depressive disorder induced by reserpine administration
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Lee HR, Hwang IS, Kim JE, Choi SI, Lee YJ, Goo JS, Lee EP, Choi HW, Kim HS, Lee JH, Jung YJ, Hwang DY
- KMID: 1436705
- Lab Anim Res.
- 2012 Jun;28(2):109-114.
- doi: 10.5625/lar.2012.28.2.109
Altered expression of neurotrophic factors as well as neuroinflammation is commonly associated with Major depressive disorder (MDD) and Alzheimer's disease (AD). To investigate whether or not reserpine-induced MDD affects the... -
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- Non-Steroidal Anti-Inflammatory Drugs Change Various Inflammatory Mediator-Related Gene Expression In Abeta1-42 Activated Mouse Microglial Cell
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Choi YS, Kim SH
- KMID: 2338699
- J Korean Geriatr Soc.
- 2007 Sep;11(3):130-138.
BACKGROUND: We investigated whether non-steroidal anti-inflammatory drugs(NSAIDs) could influence the expression of a few inflammatory mediator-related genes in amyloid-beta1-42(Abeta42)-activated microglia. METHODS: BV-2 cells, a murine microglial cell line, were pretreated with... -
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- Peroxiredoxin I regulates the component expression of gamma-secretase complex causing the Alzheimer's disease
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Lee YJ, Goo JS, Kim JE, Nam SH, Hwang IS, Choi SI, Lee HR, Lee EP, Choi HW, Kim HS, Lee JH, Jung YJ, Kim HJ, Hwang DY
- KMID: 1444961
- Lab Anim Res.
- 2011 Dec;27(4):293-299.
- doi: 10.5625/lar.2011.27.4.293
Peroxiredoxin I (Prx I) is a member of the peroxiredoxins (Prxs) family, which are antioxidant enzymes that regulate various cellular process via intracellular oxidative signal pathways. In order to investigate... -
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- Bacoside A Induced Sub-G0 Arrest and Early Apoptosis in Human Glioblastoma Cell Line U-87 MG through Notch Signaling Pathway
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Aithal MG, Rajeswari
- KMID: 2444792
- Brain Tumor Res Treat.
- 2019 Apr;7(1):25-32.
- doi: 10.14791/btrt.2019.7.e21
BACKGROUND: Glioblastoma multiforme (GBM) is a highly malignant brain tumor with a worst prognosis of less than one year despite advance treatment facilities. Among various signaling pathway genes displaying genetic... -
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- Effects of Red Liriope platyphylla on NGF secretion ability, NGF receptor signaling pathway and gamma-secretase components in NSE/hAPPsw transgenic mice expressing Alzheimer's Disease
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Choi SI, Goo JS, Kim JE, Hwang IS, Lee HR, Lee YJ, Son HJ, Lee HS, Lee JS, Hwang DY
- KMID: 1436720
- Lab Anim Res.
- 2012 Sep;28(3):155-163.
- doi: 10.5625/lar.2012.28.3.155
Liriope platyphylla (LP) has long been regarded as a curative herb for the treatment of diabetes, asthma, and neurodegenerative disorders. To examine the therapeutic effects of Red LP (RLP) manufactured... -
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- Beta Cells Preservation in Diabetes using GLP-1 and Its Analog
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Kim BJ
- KMID: 2168165
- Hanyang Med Rev.
- 2009 May;29(2):140-147.
Diabetes Mellitus is a metabolic disease caused by impaired insulin secretion of pancreatic beta cells and increased insulin resistance of peripheral tissues. In Asian T2DM, progressive loss of beta cells... -
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