Korean J Physiol Pharmacol.  2008 Apr;12(2):79-81. 10.4196/kjpp.2008.12.2.79.

Protective Effect of Decursinol on Mouse Models of Sepsis: Enhancement of Interleukin-10

• Jung JS
• Yan JJ
• Song DK

• KMID: 1486147
• DOI: http://doi.org/10.4196/kjpp.2008.12.2.79

Abstract

The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models of experimental sepsis, i.e., lipopolysaccharide (LPS)/D-galactosamine (GalN), high-dose LPS (20 mg/kg), and cecal ligation and puncture (CLP). Intra-peritoneal pretreatment of mice with decursinol (50 mg/kg) markedly enhanced the LPS/GalN-induced increase of plasma interleukin-10 (IL-10) levels, without affecting plasma TNF-alpha, IL-6 and IL-12 levels. These results suggest that decursinol could be effective for prevention or treatment of sepsis.

Keyword

Decursinol; Experimental sepsis; Interleukin-10

MeSH Terms

Animals
Benzopyrans
Butyrates
Interleukin-10
Interleukin-12
Interleukin-6
Ligation
Mice
Plasma
Punctures
Sepsis
Tumor Necrosis Factor-alpha
Benzopyrans
Butyrates
Interleukin-10
Interleukin-12
Interleukin-6
Tumor Necrosis Factor-alpha

Figure

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  Fig. 1. Structure of decursinol.

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  Fig. 2. Protective effect of decursinol on lethality which was induced by LPS/GalN (a), high dose LPS (b), and CLP (c). Decursinol was injected intraperitoneally (i.p.) 30 min prior to the i.p. administration of LPS/GalN (a), and high dose LPS (b). Decursinol was i.p. administered twice at 2 h and 4 h after CLP. Number of mice for each group was five (a), seven (b), and seven (c). ∗p<0.05, ∗∗ p<0.01 significantly different from vehicle-treated group.

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  Fig. 3. Enhancement of LPS/GalN-induced plasma IL-10 levels by pretreatment with decursinol. Decursinol was i.p. administered 30 min prior to the i.p. administration of LPS/GalN, and plasma levels of cytokines were measured 1.5 h after i.p. administration of LPS/GalN. Data represent means±SEM of five to seven mice. ∗∗∗p<0.001 significantly different from LPS/GalN-treated group at the time point.

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