J Korean Assoc Oral Maxillofac Surg.  2008 Feb;34(1):19-27.

Effects of fibrin glue on bone formation in combination with deproteinized bone xenografts in humans

• Kim MS
• Kim SG
• Lim SC
• Kim HK
• Moon SY

Abstract

Thirty-six sinus grafts were performed in 34 patients with an alveolar crest bone height in the posterior maxilla of 3 to 5 mm before grafting. The sinuses were grafted using Bio-Oss alone or mixed with fibrin glue. Group 1 was the control group and included 25 patients who received a xenograft mixed in saline. Group 2 comprised 9 patients who received a xenograft and fibrin glue. The study was further subdivided at the time of 9 months. This histologic study evaluated by hematoxylin-eosin (H & E) and histomorphometric analysis whether fibrin glue in combination with Bio-Oss enhances bone regeneration in sinus floor elevation in humans. The new bone formation was better in Group 2 than in Group 1, but the difference was not significant. The absorption of the graft material was faster in Group 2 than in Group 1, in the short term, but better in Group 1 over the long term, although the difference was not significant. Lamellar bone was formed earlier in Group 1 compared to Group 2, but the difference was not significant. Overall, the surgery site stabilized earlier with new bone formation in Group 2 than in Group 1, but the difference was not significant. Combining a fibrin sealant and Bio-Oss could lead to improved scaffolds for bone tissue engineering based on the synergistic effects of the biomaterials. Therefore, Bio-Oss or Bio-Oss plus Tisseel may be used depending on the situation.

Keyword

Fibrin glue; Bone formation; Deproteinized bone xenografts

MeSH Terms

Absorption
Biocompatible Materials
Bone and Bones
Bone Regeneration
Fibrin
Fibrin Tissue Adhesive
Floors and Floorcoverings
Humans
Maxilla
Minerals
Osteogenesis
Transplantation, Heterologous
Transplants
Biocompatible Materials
Fibrin
Fibrin Tissue Adhesive
Minerals