Nucl Med Mol Imaging.
2008 Apr;42(2):112-117.
Physical Artifact Correction in Nuclear Medicine Imaging: Normalization and Attenuation Correction
- Affiliations
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- 1Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
- 2Interdisciplinary programs in Radiation Applied Life Science major, Seoul National University College of Medicine, Seoul, Korea. jaes@snu.ac.kr
- 3Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
- 4Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- Artifact corrections including normalization and attenuation correction were important for quantitative analysis in Nuclear Medicine Imaging. Normalization is the process of ensuring that all lines of response joining detectors in coincidence have the same effective sensitivity. Failure to account for variations in LOR sensitivity leads to bias and high-frequency artifacts in the reconstructed images. Attenuation correction is the process of the correction of attenuation phenomenon lies in the natural property that photons emitted by the radiopharmaceutical will interact with tissue and other materials as they pass through the body. In this paper, we will review the several approaches for normalization and attenuation correction strategies.
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