Infect Chemother.  2008 Feb;40(1):52-57. 10.3947/ic.2008.40.1.52.

A Case of Chloroquine-resistant Plasmodium vivax Malaria Imported from Indonesia

• Kim ES
• Na BK
• Park YK
• Chung MH
• Lee JS
• Cheon SM
• Lee J
• Shin JH
• Kim EY
• Pai H

• KMID: 1483478
• DOI: http://doi.org/10.3947/ic.2008.40.1.52

Abstract

Resistance of falciparum malaria to antimalarial agents is prevalent in many areas, whereas chloroquine-resistant vivax malaria has been reported mainly around New Guinea since 1989. Concomitant with the spread of chloroquine-resistant P. vivax and increase in number of international travelers, imported cases of chloroquine-resistant vivax malaria in travelers returning from these areas has been reported. We experienced a case of chloroquine resistance P. vivax infection imported from Mangole Island, Indonesia. Its origin is confirmed not to be indigenous by the gene encoding analysis for the polymorphic region of apical membrane antigen-1 in P. vivax. Gene sequencing of the P. vivax mdr1 gene revealed only one substitution located at the codon 1076 (F1076L). The case was managed with oral quinidine with successful outcomes.

Keyword

Plasmodium vivax; Malaria; Chloroquine; Resistance

MeSH Terms

Antimalarials
Chloroquine
Codon
Indonesia
Malaria
Malaria, Vivax
Membranes
New Guinea
Plasmodium
Plasmodium vivax
Quinidine
Antimalarials
Chloroquine
Codon
Quinidine

Figure

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  Fig. 1 Chest radiography on day-5 shows bilateral pulmonary infiltrates.

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  Figure 2 Deduced amino acid sequence of P. vivax pvmdr1 gene of the isolate from the case. The F1076L substitution was noticed.

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