Korean J Intern Med.
1999 Jul;14(2):86-89.
Imported tertian malaria resistant to primaquine
- Affiliations
-
- 1Department of Internal Medicine, Sun General Hospital, Dae Jeon, Korea.
- 2Department of Clinical Pathology, Sun General Hospital,Dae Jeon,Korea.
Abstract
- In Plasmodium vivax and Plasmodium ovale malaria, some of the liver stage
parasites remain dormant. The activation of these dormant forms (called
hypnozoite) can give rise to relapse weeks, months or years after the initial
infection. To prevent relapses, a course of primaquine may be given as terminal
prophylaxis to patients. Different strains of Plasmodium vivax vary in their
sensitivity to primaquine and, recently, cases of relapse of Plasmodium vivax
after this standard primaquine therapy were reported from various countries. We
reported a case of primaquine resistant malaria which initially was thought to
be relapsed caused by loss of terminal prophylaxis.