Korean J Reprod Med.
2008 Mar;35(1):61-67.
Immunohistochemical Study on the Effect of Dexamethasone on the Luteolysis of Corpus Luteum of the Rat
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Chungnam National University, Daejon, Korea. nht@cnuh.co.kr
- 2Depatment of Anatomy, College of Medicine, Chungnam National University, Daejon, Korea.
Abstract
OBJECTIVE
This study was attempted to look at the effect of dexamethasone on the luteolysis of corpus luteum in rats by immunohistochemical study.
METHODS
Counting with an optical microscope was conducted to make a comparison on difference in luteolysis and penetration of macrophage into three groups: control group of 30 female rats at 8 weeks of age, dexamethasone 0.1 mg administered group, and dexamethasone 1mg administered group.
RESULTS
As a result of TUNEL immunostaining, the percentage of luteolysis was significantly reduced in both dexamethasone 0.1 mg administered group and 1 mg administered group, and after ED1 immunostaining, macrophage invasion was reduced in dexamethasone 1 mg administered group. As a consequence of ED1 immunostaining, the immune response of macrophage was much decreased in dexamethasone 1 mg administered group than control group.
CONCLUSION
Dexamethasone works on luteal cell, so it can suppress apoptosis. It can suppress luteolysis by suppression macrophage invasion into corpus luteum or suppress macrophage activation in corpus luteum.
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