J Korean Assoc Maxillofac Plast Reconstr Surg.  2009 Nov;31(6):535-540.

Oral Manifestation and Treatment of Acute Myeloid Leukemia: A Case Report

• Kim JY
• Min SK
• Lim HK
• Suh JW
• Hwang SJ

Abstract

Proliferation of abnormal hematopoietic cells with impaired differentiation, regulation and programmed cell death leads to leukemia. AML(acute myeloid leukemia) is a malignancy with malfunction of myeloid hematopoietic cells with acute behavior. The oral manifestations of the disease are posterior palate hemorrhage, gingival bleeding and gingival ulceration as a result of infection by normal oral flora and gingival infiltration by leukemic cells. A 49-year-old male patient was referred from local dental clinic. The patient was diagnosed with AML FAB M1 (acute myeloid leukemia French-American-British classification M1 myeloblastic leukemia without maturation). The oral infection focus was removed by a conservative treatment. 2 days after the dental treatment, the patient underwent chemotherapy. At 8-month follow-up, the overall outcome was excellent. Oral manifestations of AML are often the first indications of the malignancy. Therefore it is essential for dentists, especially oral and maxillofacial surgeons, to be aware of the diagnostic signs and complications associated with leukemia for better diagnosis and subsequent treatment and management.

Keyword

Acute myeloid leukemia; Oral manifestation; Dental treatment prior to chemotherapy

MeSH Terms

Cell Death
Dental Clinics
Dentists
Follow-Up Studies
Gingival Hemorrhage
Granulocyte Precursor Cells
Hemorrhage
Humans
Leukemia
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Male
Middle Aged
Oral Manifestations
Palate
Ulcer