J Bacteriol Virol.  2009 Jun;39(2):97-102. 10.4167/jbv.2009.39.2.97.

Antimicrobial Activity of Methanol Extract from Ficus carica Leaves Against Oral Bacteria

  • 1Research Center of Bioactive Materials, Chonbuk National University, Jeonju, Korea.
  • 2Department of Dental Hygiene, College of Natural Sciences, Dongeui University, Busan, Korea.
  • 3Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul, Korea. joungdan@yuhs.ac


Ficus carica L. (fig) belongs to the mulberry tree (Moraceae) which is one of the oldest fruits in the world. It has been used as a digestion promoter and a cure for ulcerative inflammation and eruption in Korea. The present study investigated the antimicrobial activity of methanol (MeOH) extract of figs against oral bacteria. The MeOH extract (MICs, 0.156 to 5 mg/ml; MBCs, 0.313 to 5 mg/ml) showed a strong antibacterial activity against oral bacteria. The combination effects of MeOH extract with ampicillin or gentamicin were synergistic against oral bacteria. We suggest that figs could be employed as a natural antibacterial agent in oral care products.


Ficus carica (fig); Antibacterial activity; MIC/MBC; Synergistic

MeSH Terms



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