Korean J Obes.
2009 Dec;18(4):131-137.
Relationship Between C-reactive Protein and Obesity in Children
- Affiliations
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- 1Department of Family Medicine, Korea University Medical Center Guro Hospital, Korea.
- 2Department of Family Medicine, Korea University Medical Center Ansan Hospital, Korea.
- 3Division of Endocrinology & Metabolism, Korea University Medical Center Guro Hospital, Korea.
- 4Department of Endocrinology and Metabolism, Guri Hospital, Hanyang University School of Medicine, Korea. lekang@hanyang.ac.kr
Abstract
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BACKGROUND: Low grade inflammation has been proposed as a pathophysiologic mechanism of obesity. Thus, we sought to determine the relation of C-reactive protein to obesity in Korean children.
METHODS
We selected 585 children aged 9 years in Seoul. Anthropometric measurements and fasting blood samples were collected and body mass index (BMI) was calculated as weight/height2. We measured high-sensitivity CRP (hs-CRP), glucose (FBS), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and triglyceride (TG).
RESULTS
Hs-CRP concentration was positively correlated with weight, BMI, waist circumference and negatively correlated with HDL-C. On multivariate analysis, these variables emerged as independent determinants of hs-CRP concentration.
CONCLUSION
Obesity is associated with higher hs-CRP concentration. These findings suggest a state of subclinical inflammation in obese children.
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