Korean J Bone Metab.  2012 May;19(1):29-34. 10.11005/kjbm.2012.19.1.29.

Routine Application of the Korean FRAX Model in Women: a Single-center Study

• Kim TH
• Lee HH
• Chung SH
• Lee WS
• Park J
• Lee S

• KMID: 1464233
• DOI: http://doi.org/10.11005/kjbm.2012.19.1.29

Abstract

OBJECTIVES
The objective of this study was to assess the efficacy of the Korean fracture-risk assessment tool (FRAX) model for routine application in women who had a general check-up for bone mineral density (BMD).
METHODS
This retrospective study was conducted at a university hospital and comprised 343 patients, whose BMD and clinical risk factors were assessed for FRAX calculation. The 10-year probabilities of hip and major osteoporotic fractures were compared with the result of the FRAX(R) tool (http://www.shef.ac.uk/FRAX, web version 3.5) applied to Korean models developed at the World Health Organization Collaborating Center with or without femoral neck bone mineral density.
RESULTS
The T-score gradually decreased with increasing age. Additionally, the 10-year probability of a major osteoporotic fracture increased with age. However, the probability of hip fracture showed no correlation with age if BMD was not included in the estimation.
CONCLUSION
Previous report on patients whose probability of a proximal femoral fracture were calculated using Korean FRAX models produced a higher score than our data because our data involved a general population. A larger general population is needed to confirm the Korean FRAX model. However, our data provide information for physicians to assess the Korean FRAX model in the general female population.

Keyword

Bone density; Osteoporotic fractures; Risk factor; Women

MeSH Terms

Bone Density
Female
Femoral Fractures
Femur Neck
Hip
Humans
Osteoporotic Fractures
Retrospective Studies
Risk Factors
World Health Organization

Figure

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  Fig. 1 Input and output for the fracture-risk assessment tool (FRAX)® model.

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  Fig. 2 Ten-year probabilities using Korean fracture-risk assessment tool (FRAX) model according to age. (A) Major osteoporotic fracture, (B) Hip fracture. (*,†,‡,§P < 0.001 by Kruskal-Wallis test)

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