J Korean Med Sci.  2010 Nov;25(11):1657-1660. 10.3346/jkms.2010.25.11.1657.

Determination of an Applicable FRAX Model in Korean Women

• Lee DY
• Lim SJ
• Moon YW
• Min YK
• Choi D
• Yoon BK
• Park YS

• KMID: 1779238
• DOI: http://doi.org/10.3346/jkms.2010.25.11.1657

Abstract

We investigated which of the three FRAX fracture risk assessment tool models is most applicable to Korean women. For 306 postmenopausal women (mean age, 77 yr) with a hip fracture, fracture probabilities were calculated using FRAX models from Japan, Turkey and China. Data on bone mineral density (BMD) at the femoral neck were available for 103 patients. Significant differences existed among the models, independent of the inclusion of BMD in the calculation of fracture probabilities. The probabilities of both major osteoporotic fractures and hip fractures were significantly higher in the Japanese model than in the Turkish or Chinese models. In all of the models, the probabilities of a major osteoporotic fracture, but not of a hip fracture, decreased significantly if calculated without BMD values. By applying the Japanese model, the ten-year probabilities for major osteoporotic and hip fractures increased significantly with age. Our results suggest that the Japanese FRAX model might be the most appropriate for Korean women.

Keyword

FRAX; Fractures, Bone; Osteoporosis; Korea

MeSH Terms

Aged
Aged, 80 and over
Bone Density/physiology
Female
Fractures, Bone/*epidemiology/ethnology/prevention & control
Hip Fractures/epidemiology/ethnology/prevention & control
Humans
Middle Aged
*Models, Statistical
Osteoporosis, Postmenopausal/complications
Republic of Korea/epidemiology
Risk Assessment

Figure

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  Fig. 1 Ten-year fracture probabilities using Japan FRAX model according to age. (A) Major osteoporotic fracture, (B) Hip fracture. The 10-yr probabilities increase significantly according to age for both major osteoporotic fractures and hip fractures (P<0.001 by ANOVA). *P<0.05 vs inclusion of BMD by Mann-Whitney or t test, as indicated.

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