Res Vestib Sci.  2010 Mar;9(1):27-31.

The Effect of Serum Uric Acid in Generating Idiopathic Benign Paroxysmal Positional Vertigo

• Jeong SH
• Kim JS

Abstract

BACKGROUND AND OBJECTIVES
The causative role of serum uric acid has been controversial in Benign paroxysmal positional vertigo (BPPV). The aim of this study was vto determine the role of serum uric acid in developing idiopathic BPPV.
MATERIALS AND METHODS
We recruited 168 consecutive patients with a confirmed diagnosis of idiopathic BPPV. The patients comprised 116 women (age range: 29~70 years, mean+/-SD: 55.8+/-9.7 years) and 52 men (age range: 32~70 years, mean+/-SD: 55.2+/-10.9 years). The serum uric acid levels of the patients were compared with those of 194 controls (age range: 20~70 years, mean+/-SD: 55.5+/-7.8 years) without a history of dizziness.
RESULTS
The serum uric acid levels were decreased in patients with BPPV compared with those in normal controls (4.8+/-1.3 vs 5.3+/-1.3, p=0.001). However, multiple logistic regression analyses adjusted for age, sex, alcohol, smoking, hyperphosphatemia and osteopenia/osteoporosis did not demonstrate that the hypouricemia is an independent risk factor for BPPV.
CONCLUSION
This study suggests that serum uric acid level is not a risk factor for developing idiopathic BPPV.

Keyword

Uric acid; Benign paroxysmal positional vertigo

MeSH Terms

Dizziness
Female
Humans
Hyperphosphatemia
Logistic Models
Male
Risk Factors
Smoke
Smoking
Uric Acid
Vertigo
Smoke
Uric Acid
Vertigo