J Korean Assoc Oral Maxillofac Surg.  2010 Feb;36(1):39-42. 10.5125/jkaoms.2010.36.1.39.

Effect of bovine bone (Bio-Oss(R)) and platelet rich plasma, platelet poor plasma on sinus bone graft in rabbit

• Lee TH
• Jeong YM
• Choi YK
• Lee ES
• Jang HS
• Rim JS

• KMID: 1457817
• DOI: http://doi.org/10.5125/jkaoms.2010.36.1.39

Abstract

Maxillary sinus lift and bone graft are used to reconstruct atrophic maxilla molar area for endosseous dental implants. Many different grafting materials and techniques can be used for maxillary sinus bone graft. Bio-Oss(R) has been proposed as bone substitute and successfully utilized as osteoconductive filler. Platelet rich plasma (PRP) is an autologous material with many growth factors, such as PDGF, TGF-beta, IGF, VEGF, facilitating bone healing process. And Platelet poor plasma (PPP) is the by-product in procedure of producing PRP. Six rabbits were used as experimental animal. Both maxillary sinus were grafted with Bio-Oss(R) and PRP, and Bio-Oss(R) and PPP. Rabbits were sacrificed at 4, 8 and 12 weeks. The grafting sites were evaluated by histomorphometric analysis. As a result, using PRP showed excellent bone formation in the early stage, but no further significant effect after that. In late stage, the ability of bone formation of using PRP was even worse than using PPP. The further studies need to be considered in this case.

Keyword

Maxillary sinus; Bio-Oss(R); Platelet-rich plasma (PRP); Platelet poor plasma (PPP)

MeSH Terms

Animals
Blood Platelets
Bone Substitutes
Dental Implants
Intercellular Signaling Peptides and Proteins
Maxilla
Maxillary Sinus
Molar
Osteogenesis
Plasma
Platelet-Rich Plasma
Rabbits
Transforming Growth Factor beta
Transplants
Vascular Endothelial Growth Factor A
Bone Substitutes
Dental Implants
Intercellular Signaling Peptides and Proteins
Transforming Growth Factor beta
Vascular Endothelial Growth Factor A

Figure

• 

  Fig. 1. A. Bio-Oss® + PRP, 4 weeks. B. Bio-Oss® + PRP, 8 weeks. C. Bio-Oss® + PRP, 12 weeks. PRP, Platelet rich plasma.

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  Fig. 2. A. Bio-Oss® + PPP, 4 weeks. B. Bio-Oss® + PPP, 8 weeks. C. Bio-Oss® + PPP, 12 weeks. PPP, Platelet poor plasma.

Reference

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