Int J Oral Biol.
2010 Sep;35(3):91-97.
Effects of Chitosan on the Differentiation of MDPC-23 Cells
- Affiliations
-
- 1Oral Biology Research Institute, Chosun University School of Dentistry, Gwangju, Korea. hjbkim@chosun.ac.kr
- 2Division in Anatomy and Developmental Biology, Department of Oral Biology, Brain Korea 21 Project, Yonsei University College of Dentistry, Seoul, Korea.
Abstract
- The effects of chitosan upon the experimentally induced differentiation of MDPC-23 cells, derived from mouse dental papilla cells, were investigated by RT-PCR, observations of cell morphology and Alizaline red-S staining. Chitosan was found to significantly increase and accelerate the expression of ALP mRNA but decrease the ColI transcript levels, as compared with the control, in a time-dependent manner during the differentiation of MDPC-23 cells. Chitosan also significantly downregulated ON mRNA expression and accelerated mineralization in differentiating MDPC-23 cells. These results suggest that chitosan facilitates odontoblast differentiation and mineralization and may have potential clinical applications as a dentin regeneration material.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Effects of Melatonin on MDPC-23 Cells Differentiation
- Effect of Resveratrol on Cell Differentiation and Mineralization in Cultured Odontoblasts
- MicroRNA Analysis during Cultured Odontoblast Differentiation
- Effect of Metformin on Cell Growth and Differentiation in Cultured Odontoblasts
- Biological Effects of Light-Emitting Diodes Curing Unit on MDPC-23 Cells and Lipopolysaccharide Stimulated MDPC-23 Cells
