J Korean Soc Transplant.  2010 Jun;24(2):110-113. 10.4285/jkstn.2010.24.2.110.

A Case of Lupus-Like Syndrome after Kidney Transplantation

Affiliations
  • 1Department of Internal Medicine, Seoul Paik Hospital, Seoul, Korea. puppledoc@naver.com
  • 2Department of General Surgery, Seoul Paik Hospital, Seoul, Korea.
  • 3Department of Anesthesiology, Seoul Paik Hospital, Seoul, Korea.
  • 4Department of Urology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
  • 5Department of Thoracic Surgery, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Abstract

Systemic erythematous lupus is a systemic inflammatory autoimmune disease that develops from drug, viral, or chemical irritants. We report a case of lupus-like syndrome after kidney transplantation with an unknown cause. A 55-year-old woman was admitted with severe myalgia, fever, and arthralgia 2 days previously. She had received a kidney transplantation 8 years ago, because an acute kidney injury had progressed to chronic kidney disease. After transplantation, she had no problems. We performed blood, urine, and sputum cultures but could found no microorganisms. We suspected a connective tissue disease, such as adult Still's disease, and performed autoantibody testing. As a result, antinuclear antibody was positive, and we diagnosed her with lupus-like syndrome due to an unknown cause. We increased the prednisolone dose and her symptoms improved.

Keyword

Systemic lupus erythematosus; Connective tissue diseases; Kidney transplantation

MeSH Terms

Acute Kidney Injury
Adult
Antibodies, Antinuclear
Arthralgia
Autoimmune Diseases
Connective Tissue Diseases
Female
Fever
Humans
Irritants
Kidney
Kidney Transplantation
Lupus Erythematosus, Systemic
Middle Aged
Prednisolone
Renal Insufficiency, Chronic
Sputum
Transplants
Antibodies, Antinuclear
Irritants
Prednisolone

Reference

References

6). Shen GQ, Shoenfeld Y, Peter JB. Anti-DNA, antihistone, and antinucleosome antibodies in systemic lupus erythematosus and drug-induced lupus. Clin Rev Allergy Immunol. 1998; 16:321–34.
Article
7). Goral S, Ynares C, Shappell SB, Snyder S, Feurer ID, Kazancioglu R, et al. Recurrent lupus nephritis in renal transplant recipients revisited: it is not rare. Transplantation. 2003; 75:651–6.
8). Nyberg G, Blohme I, Persson H, Olausson M, Svalander C. Recurrence of SLE in transplanted kidneys: a followup transplant biopsy study. Nephrol Dial Transplant. 1992; 7:1116–23.
9). Signori Baracat AL, Ribeiro-Alves MA, Alves-Filho G, Mazzali M. Systemic lupus erythematosus after renal transplantation: is complement a good marker for graft survival? Transplant Proc. 2008; 40:746–8.
Article
10). Stinton LM, Barr SG, Tibbles LA, Yilmaz S, Sar A, Benedikttson H, et al. Autoantibodies in lupus nephritis patients requiring renal transplantation. Lupus. 2007; 16:394–400.
Article
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