J Korean Soc Transplant.  2013 Sep;27(3):128-131. 10.4285/jkstn.2013.27.3.128.

Successful Graft Recovery from Thrombotic Acute Kidney Injury in a Kidney Transplant Patient with Antiphospholipid Syndrome

• Choi Y
• Lee H
• Yun Y
• Lee Y
• Hwang E
• Jeong H
• Kim BS

• KMID: 1495870
• DOI: http://doi.org/10.4285/jkstn.2013.27.3.128

Abstract

Antiphospholipid syndrome nephropathy (APSN) is well documented in the literature as the renal involvement of the antiphospholipid syndrome (APS). A review of literature also shows that among antiphospholipid antibodies, lupus anticoagulant (LA) positivity is recognized as the strongest risk factor for APSN. In addition, APSN is also known to be associated with a poor functional outcome in the first posttransplant year. Therefore, it is a general belief that renal transplantation may be life threatening in APS patients. Furthermore, the presence of LA at the time of transplantation is particularly associated with a high rate of allograft APSN and the consequent poor transplantation outcomes. Here, we report the case that thrombotic acute kidney injury due to APSN after kidney transplantation can be successfully treated if anticoagulation therapy is timely applied with a prompt diagnosis.

Keyword

Antiphospholipid syndrome nephropathy; Antiphospholipid syndrome; Antiphospholipid antibodies; Lupus coagulation inhibitor; Kidney transplantation

MeSH Terms

Acute Kidney Injury
Antibodies, Antiphospholipid
Antiphospholipid Syndrome
Humans
Kidney
Kidney Transplantation
Lupus Coagulation Inhibitor
Risk Factors
Transplantation, Homologous
Transplants
Antibodies, Antiphospholipid
Lupus Coagulation Inhibitor