Clin Pediatr Hematol Oncol.  2011 Oct;18(2):103-108.

Effect of Preoperative Chemotherapy on Outcome of Wilms Tumor

Affiliations
  • 1Department of Pediatrics, Korea Cancer Central Hospital, Seoul, Korea.
  • 2Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kwsped@skku.edu
  • 3Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 4Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

BACKGROUND
Wilms tumor is the most common renal tumor in children. The aim of this study was to assess the effect of preoperative chemotherapy after needle biopsy on outcome of Wilms tumor and suggest an optimal treatment scheme on Wilms tumor.
METHODS
We reviewed the medical records of 52 patients who were diagnosed with Wilms tumor from 1995 to 2010. Before 2000, primary nephrectomy was usually done. After 2000, preoperative chemotherapy was usually done.
RESULTS
Preoperative chemotherapy was given to 39 cases while primary nephrectomy was done in 13 cases. Five year survival rate and five year event-free survival rate were 96.2+/-2.7% and 87.9+/-4.7%, respectively. Tumor spillage occurred more frequently in primary nephrectomy group than in preoperative chemotherapy after needle biopsy group (P=0.014). There was no significant difference in survival between the two groups (P=0.599).
CONCLUSION
Preoperative chemotherapy after needle biopsy improved diagnostic accuracy and decreased tumor spillage while strengthened chemotherapy intensity. Further studies are needed to optimize chemotherapy intensity.

Keyword

Wilms tumor; Neoadjuvant chemotherapy; Fine needle biopsy; Survival rate; Tumor spillage

MeSH Terms

Biopsy, Fine-Needle
Biopsy, Needle
Child
Disease-Free Survival
Humans
Medical Records
Nephrectomy
Survival Rate
Wilms Tumor
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