Nucl Med Mol Imaging.
2011 Dec;45(4):255-260.
Clinical Significance of F-18 FP-CIT Dual Time Point PET Imaging in Idiopathic Parkinson's Disease
- Affiliations
-
- 1Department of Radiology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea.
- 2Department of Radiology, Institute of Catholic Integrative Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, 665 Bupyeong-dong, Bupyeong-gu, Incheon 403-720, Korea. yongan@catholic.ac.kr
- 3Department of Neurology, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, 665 Bupyeong-dong, Bupyeong-gu, Incheon 403-720, Korea.
Abstract
- PURPOSE
The purpose of this study was to investigate the diagnostic value of dual time point F-18 FP-CIT PET imaging in idiopathic Parkinson's disease (PD).
MATERIALS AND METHODS
Twenty-four patients with PD (mean age 69.6) and 18 healthy people (mean age 70.26) underwent two sequential PET/CT scans (dual time point imaging) at 90 and 210 min after F-18 FP-CIT injection. Tracer activity of region of interest was measured in the caudate, putamen and a reference region in the brain from both time points. The outcome parameter was the striatooccipital ratio (SOR). Normal SOR values were obtained in the control group. The percent change in tracer activity between 90- and 210-min images was calculated. The SOR values and the percent change in tracer activity were compared between the patients and healthy control group.
RESULTS
The SOR values for the caudate, anterior and posterior putamen at both 90- and 210-min images were significantly reduced in the patients with PD. The lowest P value was obtained for the anterior and posterior putamen (p<0.001) at both time points. There were significant differences of the percent change in tracer activity for the anterior and posterior putamen in the two groups (p=0.01).
CONCLUSIONS
F-18 FP-CIT PET scans at 90 and 210 min after injection are both able to diagnose PD. Therefore, the 90-min image by itself is sufficient for diagnosing PD.
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