Korean J Pathol.  2011 Jun;45(3):311-314. 10.4132/KoreanJPathol.2011.45.3.311.

A Case of Intimal Sarcoma Arising in the Left Common Iliac Artery

• Park JY
• Kwon KY
• Kim HT
• Lee SS

• KMID: 1443739
• DOI: http://doi.org/10.4132/KoreanJPathol.2011.45.3.311

Abstract

Primary tumors of the great vessels are rare. Most encountered cases are sarcomas which most commonly develop in the aorta, pulmonary artery, and inferior vena cava. We experienced an intimal sarcoma arising in the left common iliac artery in a 68-year-old male, who suffered from claudication in his left lower extremity for a year and was diagnosed as arteriosclerosis obliterans, clinically. Bypass surgery was performed on the obstructive lesion. Grossly, the vascular lumen was filled with dark hemorrhagic materials. Microscopically, the lesion showed proliferation of anaplastic spindle cells with a marked nuclear atypia, arranged haphazardly. There were numerous mitotic figures. Foci of cholesterol clefts were also found in the intima. Immunohistochemically, the tumor cells were positive for vimentin, smooth muscle actin, and cytokeratin in certain areas. Stains for CD34, desmin, myosin heavy chain, caldesmon, and S-100 protein were negative. A pathologic diagnosis was made as intimal sarcoma with myofibroblastic differentiation.

Keyword

Intimal sarcoma; Common iliac artery; Arteriosclerosis obliterans

MeSH Terms

Actins
Aged
Aorta
Arteriosclerosis Obliterans
Calmodulin-Binding Proteins
Cholesterol
Coloring Agents
Desmin
Humans
Iliac Artery
Keratins
Lower Extremity
Male
Muscle, Smooth
Myofibroblasts
Myosin Heavy Chains
Pulmonary Artery
S100 Proteins
Sarcoma
Vena Cava, Inferior
Vimentin
Actins
Calmodulin-Binding Proteins
Cholesterol
Coloring Agents
Desmin
Keratins
Myosin Heavy Chains
S100 Proteins
Vimentin