Korean J Obes.  2012 Sep;21(3):175-182. 10.7570/kjo.2012.21.3.175.

Metabolic Syndrome is Associated with Low Adiponectin Level and Increased Insulin Resistance in Apparently Healthy Koreans

• Yoo KH
• Oh IM
• Park JE
• Kim MJ
• Park JS
• Park SJ
• Jang EJ
• Park SW
• Kim SJ
• Yoon YS
• Joung HJ
• Baik HW

• KMID: 1437235
• DOI: http://doi.org/10.7570/kjo.2012.21.3.175

Abstract

BACKGROUND
Previous studies identified that a low adiponectin level plays a significant role in the development of metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between adiponectin and MetS and its components in apparently healthy Koreans.
METHODS
We performed a cross-sectional study in a sample of Koreans aged 30~59 years, including 256 men and 340 women. Study subjects were recruited by advertisement in Bundang and all had unremarkable medical histories. MetS was defined according to the 2009 Joint Interim Statement criteria. Serum adiponectin concen-trations were measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS
The mean ages of study subjects were 43.4 +/- 8.1 for men and 44.3 +/- 8.1 for women. Both men and women with MetS had significantly lower adiponectin levels and significantly higher HOMA-IR scores. The odds ratios (OR) for MetS in men and women with adiponectin levels in the lowest tertile were 3.56 (95% CI 1.83~6.91) and 6.38 (95% CI 2.35~17.3) compared with highest tertial, respectively. There was also a significant linear decrease with increasing tertiles of adiponectin levels in both men and women. This association between adiponectin and MetS was still significant after adjustment for age, BMI, and log HOMA-IR score in men. However, in women, this association disappeared after full adjustment (age, BMI, log HOMA-IR score).
CONCLUSION
Adipo-nectin levels are independently associated with MetS and its components in apparently healthy Koreans. The relationship between low adiponectin levels and MetS was independent of insulin resistance in men, but not women.

Keyword

Metabolic syndrome; Low adiponectin level; Insulin resistance

MeSH Terms

Adiponectin
Aged
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Insulin
Insulin Resistance
Joints
Male
Odds Ratio
Adiponectin
Insulin