Toxicol Res.  2012 Dec;28(4):249-253.

Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema

Affiliations
  • 1Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Suwon, Korea. amy@rda.go.kr

Abstract

In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.

Keyword

Edema; Bumblebee alcohol extract

MeSH Terms

Animals
Edema
Endothelial Cells
Larva
Pulmonary Artery
Pupa
Rats
Vasodilation
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