Korean J Urogenit Tract Infect Inflamm.  2014 Oct;9(2):86-92. 10.14777/kjutii.2014.9.2.86.

Anti-Inflammatory Effect of Phlorotannin on Chronic Nonbacterial Prostatitis in a Rat Model

• Jung YS
• Cho YH
• Han CH

• KMID: 1732620
• DOI: http://doi.org/10.14777/kjutii.2014.9.2.86

Abstract

PURPOSE
Chronic nonbacterial prostatitis and chronic pelvic pain syndrome account for 90-95% of all prostatitis. Little is known about its pathophysiology, thus, various treatments are used. Ecklonia cava, a seaweed, is a member of the brown algae family; many recent reports have demonstrated that its extract containing phlorotannin has anti-oxidative and anti-inflammatory properties. Using the hormone-induced prostatitis rat model, we investigated the anti-inflammatory effects of E. cava extracts via its anti-oxidative process on chronic nonbacterial prostatitis.
MATERIALS AND METHODS
Forty, 10-week-old male white Wistar rats were utilized, and divided equally into the following five groups: 1) control, 2) E. cava-fed, 3) hormone-induced prostatitis (HIP), 4) E. cava-treated HIP, and 5) nonsteroidal anti-inflammatory drug (NSAID)-treated HIP.
RESULTS
The results showed statistically-significant improvement in the tissue response to the hormone-induced inflammation among the E. cava-treated and NSAID-treated groups (p<0.05). Lower malonedialdehyde levels were observed in the group with E. cava-treated HIP than with HIP alone, which was statistically significant. We believe that this supports the anti-oxidative properties of E. cava.
CONCLUSIONS
This study demonstrates that phlorotannin has anti-inflammatory properties via its anti-oxidative process, which we expect to play an important role in prevention and as an adjuvant therapy for chronic nonbacterial prostatitis.

Keyword

Prostatitis; Estrogens; Anti-inflammatory agents

MeSH Terms

Anti-Inflammatory Agents
Estrogens
Hip
Humans
Inflammation
Male
Models, Animal*
Pelvic Pain
Phaeophyta
Prostatitis*
Rats, Wistar
Seaweed
Anti-Inflammatory Agents
Estrogens

Figure

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  Fig. 1. Prostate section of control group. There is no evidence of chronic inflammatory cell infiltration, acinar change and interstitial fibrosis (H&E stain, ×100).

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  Fig. 2. Prostate section of hormone-induced prostatitis group. Severe chronic inflammatory cell infiltration and interstitial fibrosis are seen. The acinar structures are severely atrophied (H&E stain, ×100).

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  Fig. 3. Prostate section of Ecklonia cava-treated group. Mild infiltration of chronic inflammatory cells, mildly atrophied acini, and mild interstitial fibrosis are seen (H&E stain, ×100).

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  Fig. 4. Severity scores of chronic inflammatory cell infiltration, acinar changes and interstitial fibrosis in each group. ∗p＜0.05 compared with hormone-induced prostatitis (HIP) group. NSAID: nonsteroidal antiinflammatory drug.

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  Fig. 5. Mean malonedialdehyde (MDA) values measured in each group. ∗p＜0.05 compared with control group; †p＜0.05 compared with hormone-induced prostatitis (HIP) group. NSAID: nonsteroidal antiinflammatory drug.

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