Clin Exp Reprod Med.  2013 Mar;40(1):38-41. 10.5653/cerm.2013.40.1.38.

Ovarian stimulation and liver dysfunction: Is a clinical relationship possible? A case of hepatic failure after repeated cycles of ovarian stimulation

• Giugliano
• Cagnazzo E
• Pansini G
• Vesce F
• Marci R

• KMID: 1430082
• DOI: http://doi.org/10.5653/cerm.2013.40.1.38

Abstract

Liver damage induced by ovarian stimulation has been demonstrated in some cases reported in the literature. However, there has never been a fruitful debate on this topic. The present manuscript tried to fill this gap. We reported a case of a 35-year-old nulliparous woman admitted to our obstetric emergency room for severe pre-eclampsia. She had been subjected to four cycles of controlled ovarian stimulation for intrauterine insemination. At 32 weeks of gestation, she developed severe pre-eclampsia, which led to HELLP syndrome complicated by fatal liver failure. The etiological link between ovarian stimulation and HELLP syndrome is intriguing. Further investigations are needed to understand whether repeated ovarian stimulation may represent a risk factor in pre-eclamptic patients.

Keyword

Controlled ovarian stimulation; Endothelial dysfunction; HELLP syndrome; Intrauterine insemination; Liver rupture; Ovarian hyperstimulation syndrome

MeSH Terms

Aluminum Hydroxide
Carbonates
Emergencies
Female
Fruit
HELLP Syndrome
Humans
Insemination
Liver
Liver Failure
Ovarian Hyperstimulation Syndrome
Ovulation Induction
Pre-Eclampsia
Pregnancy
Risk Factors
Aluminum Hydroxide
Carbonates