Clin Exp Reprod Med.  2013 Jun;40(2):95-99. 10.5653/cerm.2013.40.2.95.

Association between serum anti-Mullerian hormone level and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome

• Kim JY
• Yi G
• Kim YR
• Chung JY
• Ahn JH
• Uhm YK
• Jee BC
• Suh CS
• Kim SH

• KMID: 1493216
• DOI: http://doi.org/10.5653/cerm.2013.40.2.95

Abstract

OBJECTIVE
To evaluate the correlation between serum levels of anti-Mullerian hormone (AMH) and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome (PCOS).
METHODS
Seventy-four cycles of mild stimulation (clomiphene citrate+gonadotropin followed by timed intercourse or intrauterine insemination) performed in normoovulatory women (57 cycles) and anovulatory women with PCOS (17 cycles). Ovarian sensitivity was defined by the number of mature follicles (> or =14 mm) on triggering day per 100 IU of gonadotropin. A correlation between ovarian sensitivity and the baseline serum AMH level (absolute or multiples of the median [MoM] value for each corresponding age) was calculated. Correlation between ovarian response and serum AMH level was evaluated.
RESULTS
Ovarian sensitivity to mild stimulation was positively correlated with absolute serum AMH (r=0.535, p<0.001) or AMH-MoM value (r=0.390, p=0.003) in normoovulatory women, but this correlation was not observed in anovulatory women with PCOS (r=0.105, p>0.05, r=-0.265, p>0.05, respectively).
CONCLUSION
Ovarian response to mild stimulation is possibly predicted by the serum AMH level in normoovulatory women, but not in anovulatory women with PCOS.

Keyword

Anti-Mullerian hormone; Ovarian stimulation; Polycystic ovary syndrome

MeSH Terms

Anti-Mullerian Hormone
Female
Gonadotropins
Humans
Ovulation Induction
Polycystic Ovary Syndrome
Anti-Mullerian Hormone
Gonadotropins