Exp Mol Med.
2012 Nov;44(11):665-673.
Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term diabetes
- Affiliations
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- 1East-West Bone and Joint Research Institute, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul 134-727, Korea. labrea46@yahoo.co.kr
- 2Department of Endocrinology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul 134-727, Korea. jik1016@dreamwiz.com
- 3Core Research Laboratory, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul 134-727, Korea.
- 4Department of Pathology, Inje University Sanggye Paik Hospital, Seoul 139-707, Korea.
- 5Department of Food and Nutrition, Inha University, Incheon 402-751, Korea.
- 6Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul 134-727, Korea.
Abstract
- This study aimed to determine whether taurine supplementation improves metabolic disturbances and diabetic complications in an animal model for type 2 diabetes. We investigated whether taurine has therapeutic effects on glucose metabolism, lipid metabolism, and diabetic complications in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term duration of diabetes. Fourteen 50-week-old OLETF rats with chronic diabetes were fed a diet supplemented with taurine (2%) or a non-supplemented control diet for 12 weeks. Taurine reduced blood glucose levels over 12 weeks, and improved OGTT outcomes at 6 weeks after taurine supplementation, in OLETF rats. Taurine significantly reduced insulin resistance but did not improve beta-cell function or islet mass. After 12 weeks, taurine significantly decreased serum levels of lipids such as triglyceride, cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol. Taurine significantly reduced serum leptin, but not adiponectin levels. However, taurine had no therapeutic effect on damaged tissues. Taurine ameliorated hyperglycemia and dyslipidemia, at least in part, by improving insulin sensitivity and leptin modulation in OLETF rats with long-term diabetes. Additional study is needed to investigate whether taurine has the same beneficial effects in human diabetic patients.
MeSH Terms
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Adipokines/blood
Animals
Blood Glucose
Diabetes Mellitus, Type 2/drug therapy
Dietary Supplements
Dyslipidemias/blood/*drug therapy
Glucose Tolerance Test
Hyperglycemia/blood/*drug therapy
Hypoglycemic Agents/administration & dosage/*pharmacology
Hypolipidemic Agents/administration & dosage/*pharmacology
Insulin/physiology/secretion
Insulin Resistance
Insulin-Secreting Cells/physiology/secretion
Leptin/*blood
Lipid Metabolism/drug effects
Lipids/blood
Male
Organ Specificity
Rats
Rats, Long-Evans
Taurine/administration & dosage/*pharmacology
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