- Beneficial Effects of Thiazolidinediones on Diabetic Nephropathy in OLETF Rats
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Lee MY, Lee EY, Lee BJ, Won CS, Koh JH, Shin JY, Shin YG, Cho BP, Chung CH
- KMID: 1779535
- Yonsei Med J.
- 2007 Apr;48(2):301-307.
- doi: 10.3349/ymj.2007.48.2.301
PURPOSE: Diabetic nephropathy is the most serious of complications in diabetes mellitus. Thiazolidinedione (TZD) is thought to ameliorate diabetic nephropathy; however, the mechanism underlying this effect has not been elucidated.... -
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- COMP-Angiopoietin-1 Promotes Cavernous Angiogenesis in a Type 2 Diabetic Rat Model
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Kim SO, Lee HS, Ahn K, Park K
- KMID: 1777560
- J Korean Med Sci.
- 2013 May;28(5):725-730.
- doi: 10.3346/jkms.2013.28.5.725
Cartilage oligomeric matrix protein-angiopoietin-1 (COMP-Ang1) is an angiogenic factor for vascular angiogenesis. The aim was to investigate the effect of an intracavernosal injection of COMP-Ang1 on cavernosal angiogenesis in a... -
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- Peroxisome Proliferator-Activated Receptor-Gamma Expression in the Lung Tissue of Obese Rats
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Hwang SJ, Kim JH, Shim JW, Kim DS, Jung HL, Park MS, Lee WY, Kim SY, Shim JY
- KMID: 1777023
- Yonsei Med J.
- 2011 May;52(3):495-501.
- doi: 10.3349/ymj.2011.52.3.495
PURPOSE: Obesity is a risk factor for asthma and type II diabetes. Peroxisome proliferator-activated receptor (PPAR)-gamma has been suggested to regulate inflammatory responses in diabetes and asthma. We investigated whether... -
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- Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term diabetes
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Kim KS, Oh DH, Kim JY, Lee BG, You JS, Chang KJ, Chung H, Yoo MC, Yang HI, Kang JH, Hwang YC, Ahn KJ, Chung HY, Jeong IK
- KMID: 1401758
- Exp Mol Med.
- 2012 Nov;44(11):665-673.
This study aimed to determine whether taurine supplementation improves metabolic disturbances and diabetic complications in an animal model for type 2 diabetes. We investigated whether taurine has therapeutic effects on... -
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- Neurotrophin Toxicity in Iron-Induced Experimental Spinal Cord Injury in Rat
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Shin H
- KMID: 2174642
- J Korean Acad Rehabil Med.
- 2001 Feb;25(1):62-68.
OBJECTIVE: The purpose of this study is to determine neurotrophin effect in Fe++-induced experimental spinal cord injury in adult female rat. METHOD: Thirty Long-Evans rats (weight, 250 to 300 gr)... -
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- Protective Effects of Curcumin on Renal Oxidative Stress and Lipid Metabolism in a Rat Model of Type 2 Diabetic Nephropathy
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Kim BH, Lee ES, Choi R, Nawaboot J, Lee MY, Lee EY, Kim HS, Chung CH
- KMID: 2374087
- Yonsei Med J.
- 2016 May;57(3):664-673.
- doi: 10.3349/ymj.2016.57.3.664
PURPOSE: Diabetic nephropathy is a serious complication of type 2 diabetes mellitus, and delaying the development of diabetic nephropathy in patients with diabetes mellitus is very important. In this study,... -
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- Effect of Diamine Bridges Using L-lysine in Glutaraldehyde Treated Porcine Pericardium
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Kim KC, Choi YK, Kim SH, Kim YJ
- KMID: 1475310
- Korean J Thorac Cardiovasc Surg.
- 2009 Apr;42(2):157-164.
BACKGROUND: Various studies and experimental trials have been done to develop bioprosthetic devices to treat complex congenital heart disease due to the limited usage of homograft tissue. The purpose of... -
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- Glutamine Synthetase Induced Spinal Seizures in Rats
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Shin DW, Yoon YS, Matsumoto , Huang W, Ceraulo P, Young W
- KMID: 1719079
- Yonsei Med J.
- 2003 Feb;44(1):125-132.
- doi: 10.3349/ymj.2003.44.1.125
Glutamine synthetase (GS) is a key enzyme in the regulation of glutamate neurotransmission in the central nervous system. It is responsible for converting glutamate to glutamine, consuming one ATP and... -
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- Anti-Proliferative Effects of Rutin on OLETF Rat Vascular Smooth Muscle Cells Stimulated by Glucose Variability
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Yu SH, Yu JM, Yoo HJ, Lee SJ, Kang DH, Cho YJ, Kim DM
- KMID: 2374042
- Yonsei Med J.
- 2016 Mar;57(2):373-381.
- doi: 10.3349/ymj.2016.57.2.373
PURPOSE: Proliferation of vascular smooth muscle cells (VSMCs) plays a crucial role in atherosclerosis. Rutin is a major representative of the flavonol subclass of flavonoids and has various pharmacological activities.... -
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- Therapeutic time window for methylprednisolone in spinal cord injured rat
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Yoon DH, Kim YS, Young W
- KMID: 711655
- Yonsei Med J.
- 1999 Aug;40(4):313-320.
- doi: 10.3349/ymj.1999.40.4.313
Recent clinical trials have reported that methylprednisolone sodium succinate administered within 8 hours improves neurological recovery in human spinal cord injury (SCI). Methylprednisolone, however, was ineffective and possibly... -
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- Peroxisome proliferator-activated receptor delta agonist attenuates hepatic steatosis by anti-inflammatory mechanism
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Lee MY, Choi R, Kim HM, Cho EJ, Kim BH, Choi YS, Naowaboot , Lee EY, Yang YC, Shin JY, Shin YG, Chung CH
- KMID: 1506221
- Exp Mol Med.
- 2012 Oct;44(10):578-585.
Although peroxisome proliferator receptor (PPAR)-alpha and PPAR-gamma agonist have been developed as chemical tools to uncover biological roles for the PPARs such as lipid and carbohydrate metabolism, PPAR-delta has not... -
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- Microarray for Genes Associated with Signal Transduction in Diabetic OLETF Keratocytes
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Lee JE, Lee JS, Hwang SH
- KMID: 1101914
- Korean J Ophthalmol.
- 2007 Jun;21(2):111-119.
- doi: 10.3341/kjo.2007.21.2.111
PURPOSE: The purpose of this study was to identify differences in signal transduction gene expression between normal and diabetic keratocytes stimulated with interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha). ... -
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