J Korean Acad Nurs.  2012 Aug;42(4):517-524. 10.4040/jkan.2012.42.4.517.

Impact of Prepregnancy Body Mass Index on Pregnancy Outcome in Women with a Singleton Conceived by Assisted Reproductive Technology and Spontaneously Conceived Pregnancy: A Case-control Study

• Kim JH
• Shin HS
• Park BK
• Yang KM
• Lee YH
• Ryu HM

• KMID: 1387324
• DOI: http://doi.org/10.4040/jkan.2012.42.4.517

Abstract

PURPOSE
To compare and confirm the impact of prepregnancy body mass index on pregnancy outcome in women with a singleton conceived by assisted reproductive technology and spontaneously conceived pregnancy.
METHODS
A sample of 165 and 247 pregnant women with and without assisted reproductive technology were retrospectively recruited from electronic medical charts of C hospital.
RESULTS
There were significant differences between the two groups for maternal age, paternal age, length of marriage, prepregnancy body mass index, parity, spontaneous abortion experience, and preterm delivery. A prepregnancy body mass index of > or =25 was associated with higher risk for maternal and neonatal complication in the assisted reproductive technology group.
CONCLUSION
The results indicate that a higher prepregnancy body mass index is associated with increased risks for adverse pregnancy outcomes for women using assisted reproductive technology. So these women need appropriate care to compensate for the risk.

Keyword

Body mass index; Weight gain; Pregnancy outcome; Assisted reproductive technology

MeSH Terms

Abortion, Spontaneous
Adult
*Body Mass Index
Case-Control Studies
Female
Humans
Infant, Low Birth Weight
Infant, Newborn
Odds Ratio
Pregnancy
Pregnancy Complications/etiology
Pregnancy Outcome
Premature Birth/etiology
Reproductive Techniques, Assisted
Retrospective Studies
Risk Factors
Weight Gain

Reference

References

Barau G.., Robillard P.., Hulsey T. C.., Dedecker F.., Laffite A.., Gerardin P., et al2006. Linear association between maternal pre-pregnancy body mass index and risk of caesarean section in term deliveries. British Journal of Obstetrics and Gynecology. 1173–1177. http://dx.doi.org/10.1111/j.1471-0528.2006.01038.x.

Centers for Disease Control and Prevention. 2009. Assisted reproductive technology surveillance-United States, 2006. MMWR Surveillance Summery. 58:1–25.

Chen Z.., Du J.., Shao L.., Zheng L.., Wu M.., Ai M., et al2010. Prepreg-nancy body mass index, gestational weight gain, and pregnancy outcomes in China. International Journal of Gynecology and Obstetrics. 109:41–44. http://dx.doi.org/10.1016/j.ijgo.2009.10.015.

Catalano P. M.., Ehrenberg H.M. 2006. The short- and long- term implications of maternal obesity on the mother and her offspring. British Journal of Obstetrics and Gynecology. 113:1126–1133. http://dx.doi.org/10.1111/j.1471-0528.2006.00989.x.

Dokras A.., Baredziak L.., Blaine J.., Syrop C.., VanVoorhis B. J.., Sparks, A. 2006. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstetrics and Gynecology. 108(1):61–69. http://dx.doi.org/10.1097/01.AOG.0000219768.08249.b6.

Fedorcsak P.., Dale P. O.., Storeng R.., Ertzeid G.., Bjercke S.., Oldereid N., et al2004. Impact of overweight and underweight on assisted reproduction treatment. Human Reproduction. 19:2523–2528. http://dx.doi.org/10.1093/humrep/deh485.

Helmerhorst F. M.., Perquin D. A. M.., Donker D.., Keirse M. J. N.C. 2004. Perinatal outcome of singletons and twins after assisted conception: A systematic review of controlled studies. British Medical Journal. 328:261. http://dx.doi.org/10.1136/bmj.37957.560278.EE.

Henningsen A. A.., Pinborg A.., Lidegaard Q.., Ves tergaard C.., Forman J. L.., Andersen A.N. 2011. Perinatal outcome of singleton siblings born after assisted reproductive technology and spontaneous conception: Danish national sibling-cohort study. Fertility and Sterility. 95(3):959–963. http://dx.doi.org/10.1016/j.fertnstert.2010.07.1075.

Jackson R. A.., Gibdon K. A.., Wu Y. W.., Croughan M.S. 2004. Perinatal outcomes in singleton following in vitro fertilization: A meta-analysis. Obstetrics and Gynecology. 103:551–563.

Koh K.S. 1998. Gestational weight gain and perinatal outcomes by maternal body mass index. Journal of the Korean Society of Maternal and Child Health. 2(2):171–180.

Koh K. S.., Park C.H. 1997. The relationship between maternal body mass index, gestational weight gain patterns and preterm birth. Korean Journal of Obstetrics and Gynecology. 40(10):2168–2177.

Leung T. Y.., Leung T. N.., Sahota D. S.., Chan O. K.., Chan L. W.., Fung T. Y., et al2008. Trends in maternal obesity and associated risks of adverse pregnancy outcomes in a population of Chinese women. British Journal of Obstetrics and Gynecology. 115:1529–1537. http://dx.doi.org/10.1111/j.1471-0528.2008.01931.x.

Luke, B. 2011. The role of obesity in reproduction. Biennial Review of Infertility. 2:35–42. http://dx.doi.org/10.1007/978-1-4419-8456-2_4.

Maheshwari A.., Stofberg L.., Bhattacharya, S. 2007. Effect of overweight and obesity on assisted reproductive technology-A systematic review. Human Reproduction Update. 13(5):433–444. http://dx.doi.org/10.1093/humupd/dmm017.

McDonald S. D.., Han Z.., Mulla S.., Beyene, J. 2010. Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: Systemic review and meta analyses. British Medical Journal. 341:1–20. http://dx.doi.org/10.1136/bmj.c3428.

Metwally M.., Ong K. I.., Ledger W. L.., Li T.C. 2008. Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertility and Sterility. 90:714–726. http://dx.doi.org/10.1016/j.fertnstert.2007.07.1290.

Ministry of Health and Welfare & Hanyang University. 2008. The study for social causative factors of infertility. Seoul: Author.

Mutsaerts M. A. Q.., Groen H.., Bogt N. C. W.., Bolster J. H. T.., Land J. A.., Bemelmans W. J. E., et al2010. The lifestyle study: Costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomized controlled trial. British Medical Council, Women's Health. 10(22):1–9. http://dx.doi.org/10.1186/1472-6874-10-22.

Reddy U. M.., Wapner R. J.., Rebar R. W.., Tasca R.J. 2007. Infertility, as- sisted reproductive technology, and adverse pregnancy outcomes. Obstetrics Gynecology. 109:967–977. http://dx.doi.org/10.1097/01.AOG.0000259316.04136.30.

Romundstad L. B.., Romundstad P.., Sunde A.., During V.., Skjarven R.., Gunnel D., et al2008. Effects of technology or maternal factors on perinatal outcome after assisted fertilization: A population-based cohort study. Lancet. 372:737–743. http://dx.doi.org/10.1016/S0140-6736(08)61041-7.

Stothard K. J.., Tennant P. W.., Bell R.., Rankin, J. 2009. Maternal overweight and obesity and the risk of congenital anomalies. A systematic review and meta-analysis. Journal of the American Medical Association. 301(6):636–650. http://dx.doi.org/10.1001/jama.2009.113.

Tepper N. K.., Farr S. L.., Cohen B. B.., Nannini A.., Zhang Z.., Anderson J. E., et al2012. Singleton preterm birth: Risk factors and association with assisted reproductive technology. Maternal Child Health Journal. 16(4):807–813. http://dx.doi.org/10.1007/s10995-011-0787-8.

Veleva Z.., Tiitinen A.., Vilska S.., Hyden-Granskog C.., Tomas C.., Mar-tikainen H., et al2008. High and low BMI increase the risk of miscarriage after IVF/ICSI and FET. Human Reproduction. 23(4):878–884. http://dx.doi.org/10.1093/humrep/den017.

Weiss J. L.., Malone F. D.., Emig D.., Ball R. H.., Nyberg D. A.., Comtock C. H., et al2004. Obesity, obstetric complications and cesarean delivery rate- a population based screening study. American Journal of Obstetrics and Gynecology. 190:1091–1097. http://dx.doi.org/10.1016/j.ajog.2003.09.058.

Wisborg K.., Ingerslev H. J.., Henriksen T.B. 2010. In vitro fertilization and preterm delivery, low birth weight, and admission to the neonatal intensive care unit: A prospective follow-up study. Fertility and Sterility. 94:2102–2106. http://dx.doi.org/10.1016/j.fertnstert.2010.01.014.

World Health Organization. 2000. Obesity: Preventing and managing the global epidemic. WHO technical report series 894. Geneva, Switzerland: Author.