Korean J Obstet Gynecol.  1999 Aug;42(8):1661-1664.

Analysis of Results of Serum Triple Marker Screening test between In Vitro Fertilization and Naturally Conceived Pregnancy

• Lee SG
• Shin SJ

Abstract

OBJECTIVE
To evaluate the results of second-trimester maternal serum triple-marker screening test for Down syndrome and open neural tube defects in singleton pregnancies conceived from in vitro fertilization, the screen positive rates and triple-marker level of patients conceiving singleton pregnancies by IVF were compared to those of pregnancies conceived naturally.
METHODS
Two hundred singleton pregnancies conceived by IVF and naturally conceived pregnancies who had done maternal serum screening test during the second trimester were analyzed from January 1995 to April 1998.
RESULTS
One (0.5%) of the 200 cases of IVF singleton pregnancies had a positive result for Down syndrome compared with 1% of screen positive rate in the 200 cases of naturally conceived pregnancies. The median level of the triple markers were 0.92 multiples of the median(MoM) for alpha-fetoprotein(AFP), 1.44 MoM for unconjugated estriol(E3) and 0.87 MoM for human chorionic gonadotropin(hCG) respectively.
CONCLUSION
The positive rate of triple test for Down syndrome and open neural tube defect in the two groups were significantly not different. As additional data are collected, corrected standards should be determined.

Keyword

Down syndrome; serum triple marker; AFP; hCG; unconjugated estriol; Down

MeSH Terms

Chorion
Down Syndrome
Female
Fertilization in Vitro*
Humans
Mass Screening*
Neural Tube Defects
Pregnancy Trimester, Second
Pregnancy*