Korean J Obstet Gynecol.  1999 Sep;42(9):1914-1918.

Clinical analysis of triple marker screening test for fetal Down syndrome in midtrimester of pregnancy-Low sensitivity of triple marker screening test

• Han KC
• Kim DW
• Jeong SM
• Yang WK
• Park CB
• Shin BK
• Shin JH
• Hong SY

Abstract

OBJECTIVE
To assess the reliability of triple marker screening test in midtrimester pregnancy for fetal Down syndrome.
METHODS
From October 1, 1996 to May 31, 1998 at Nowon Eulji Hospital, 3700 Pregnant women underwent serum tiple marker screening for Down syndrome during 15-20weeks of gestational age. The results of serum triple marker screenig tests for Down syndrome and the outcomes of pregnancies were retrospectively assesed.
RESULTS
Sixty seven of 3700 cases(1.81%) were positive in screening test, and 3633(98.18%) cases were negative. Among 67 cases of positive screening test, 1 case(1.49%) was diagnosed as Down syndrome. Among 3633 cases of negative screening test, 4 cases(0.1%) were diagnosed as chromosomal abnormalies postnatally. Two of these 4 cases of chromosomal abnormalies were Down syndrome.
CONCLUSION
With this results, sensitivity of triple marker screeing test for Down syndrome is very low as 33.3%. In order to increase the sensitivity, some compensatory adjustment is required in triple marker screening test.

Keyword

Triple serum marker; Serum screen; Pregnancy outcome; Down syndrome

MeSH Terms

Down Syndrome*
Equidae
Female
Gestational Age
Humans
Mass Screening*
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, Second*
Pregnant Women
Retrospective Studies