J Korean Soc Neonatol.  2011 Nov;18(2):197-203. 10.5385/jksn.2011.18.2.197.

Perinatal Outcomes of In Vitro Fertilized Twins in Women of Advanced Age

• Chung IH
• Kim S
• Jo HS
• Lee KH

• KMID: 2099192
• DOI: http://doi.org/10.5385/jksn.2011.18.2.197

Abstract

PURPOSE
The purpose of this study is to compare perinatal outcomes between in vitro fertilization (IVF) twins and naturally conceived twins born to women aged 35 years or older and to provide basic information for taking care of IVF twins born to women aged 35 years or older.
METHODS
We reviewed the records of perinatal and neonatal outcomes in 288 IVF twins and 220 naturally conceived twins born to women aged 35 years or older between January 2001 and December 2010 at CHA Bundang Medical Center.
RESULTS
No difference was observed in the maternal ages of mothers giving birth to IVF twins and those giving birth to naturally conceived twins. Gestational ages and birth weights of IVF twins were not different from those of naturally conceived twins. Various perinatal outcomes, including gestational diabetes mellitus, pregnancy-induced hypertension, placenta previa, premature amniotic membrane rupture, and need for a Cesarean section did not differ between the 2 groups. However, the 1-min and 5-min Apgar scores (P=0.019 and P=0.045, respectively) were different between the 2 groups. The incidence of early-onset sepsis was lower in the IVF twins than in the naturally conceived twins (P=0.02). However, the 2 groups did not show any difference in the incidence of respiratory distress syndrome, bronchopulmonary dysplasia, patent ductus arteriosus, necrotizing enterocolitis, intraventricular hemorrhage, and other congenital anomalies.
CONCLUSION
The perinatal outcomes in IVF twins born to women aged 35 years or older were not significantly different from those of naturally conceived twins.

Keyword

Maternal age; Fertilization in vitro; Twins; Perinatal motility

MeSH Terms

Aged
Amnion
Birth Weight
Bronchopulmonary Dysplasia
Cesarean Section
Diabetes, Gestational
Ductus Arteriosus, Patent
Enterocolitis, Necrotizing
Female
Fertilization in Vitro
Gestational Age
Hemorrhage
Humans
Hypertension, Pregnancy-Induced
Incidence
Infant, Newborn
Maternal Age
Mothers
Parturition
Placenta Previa
Pregnancy
Rupture
Sepsis
Twins