Korean J Parasitol.  2012 Jun;50(2):133-136. 10.3347/kjp.2012.50.2.133.

Visceral Leishmaniasis Mimicking Autoimmune Hepatitis, Primary Biliary Cirrhosis, and Systemic Lupus Erythematosus Overlap

• Tunccan OG
• Tufan A
• Telli G
• Akyurek N
• Pamukcuoglu M
• Yilmaz G
• Hizel K

• KMID: 1384741
• DOI: http://doi.org/10.3347/kjp.2012.50.2.133

Abstract

Visceral leishmaniasis (VL) is a life-threatening infection caused by Leishmania species. In addition to typical clinical findings as fever, hepatosplenomegaly, and cachexia, VL is associated with autoimmune phenomena. To date, VL mimicking or exacerbating various autoimmune diseases have been described, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and autoimmune hepatitis (AIH). Herein, we presented a patient with VL who had overlapping clinical features with SLE, AIH, as well as antimitochondrial antibody (AMA-M2) positive primary biliary cirrhosis.

Keyword

Leishmania; visceral leishmaniasis; systemic lupus erythematosus; autoimmune hepatitis; primary biliary cirrhosis

MeSH Terms

Adult
Autoantibodies/blood
Bone Marrow/pathology
Cytological Techniques
Diagnosis, Differential
Female
Hepatitis, Autoimmune/complications/*pathology
Histocytochemistry
Humans
Leishmaniasis, Visceral/complications/*diagnosis/*pathology
Liver/pathology
Liver Cirrhosis, Biliary/complications/*pathology
Lupus Erythematosus, Systemic/complications/*pathology