Korean J Ophthalmol.
1998 Jun;12(1):19-24. 10.3341/kjo.1998.12.1.19.
NF-kappa B activation following optic nerve transection
- Affiliations
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- 1Department of Ophthalmology, College of Medicine, Catholic University, Seoul, Korea.
- KMID: 1375105
- DOI: http://doi.org/10.3341/kjo.1998.12.1.19
Abstract
- In order to elucidate in vivo neuronal cell death in the retina, and involvement of NF-kappa B in this process, we studied the degeneration of retinal ganglion cells (RGCs) and the activation of NF-kappa B after transection of the optic nerve of adult rat at 5 mm from the eyeball. The morphology of dying ganglion cells in the retinal ganglion cell layer was observed by light and electron microscopy, the activation of NF-kappa B was investigated immunohistochemically. Seven and 14 days post-axotomy, dying cells contained pyknotic nuclei. The death of retinal ganglion cells involved apoptosis, activation of NF-kappa B (p50 and p65) was prominent in a time dependent manner. We observed axotomy-induced NF-kappa B activation, which may mediate apoptosis of retinal ganglion cells.
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