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In order to elucidate in vivo neuronal cell death in the retina, and involvement of NF-kappa B in this process, we studied the degeneration of retinal ganglion cells (RGCs) and...
T lymphocytes from patients with renal cell carcinoma (RCC) show reduced immune
function and impaired activation of the transcription factor, NF-kappaB. We
determined the mechanism of NF-kappaB suppression in T...
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by
persistent joint swelling and progressive destruction of cartilage and bone.
Current RA treatments are largely empirical in origin and their...
Helicobacter pylori (H. pylori) induces the activation of nuclear factor-kB (NF-kappaB) and cytokine expression in gastric epithelial cells. The Janus kinase/signal transducers and activators of transcription (Jak/Stat) cascade is the...
Transglutaminase 2 (TG2), a cross-linking enzyme, is involved in drug resistance and in the constitutive activation of nuclear factor kappa B (NF-kappaB). We investigated the association of non-small cell lung...