Korean J Nephrol.
2001 Sep;20(5):926-931.
A Case of Glomerulonephritis in Waldenstr m's Macroglobulinemia(WM) Characterized by Hyaline Thrombi in Glomerulocapillary Lumen
- Affiliations
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- 1Department of Internal Medicine, Maryknoll Hospital, Busan, Korea.
- 2Department of Clincal Pathology, Maryknoll Hospital, Busan, Korea.
- 3Department of Pathology, Maryknoll Hospital, Busan, Korea.
- 4Department of Pathology, College of Medicine, Youngnam University, Daegu, Korea.
Abstract
- Waldenstr m's macroglobulinemia(WM) is a disorder of malignant proliferation of plasmacyoid lymphocytes and monoclonal immunoglobulin M. The renal complications of WM are less common and severe than that of multiple myeloma. We present a case of WM which involved the kidney as massive proteinuria, hematuria and renal failure. A biopy specimen of the kidney reveals the intraglomerular hyaline thrombi of immunoglobulin M paraprotein. Three cycles of plasmapheresis and systemic chemotherapy with chlorambucil and prednisolone show improvement in his renal manifestations. We suppose the glomerulonephritis caused by hyaline thrombi in WM may be reversible, at least in its early stage.
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