J Korean Med Sci.  2003 Oct;18(5):669-672. 10.3346/jkms.2003.18.5.669.

The Clinical Significance of Antibody Screening Test Including Di(a+) Panel Cell in Asian-Mongoloid Populations

• Park TS
• Oh SH
• Choi JC
• Lee DD
• Kim HH
• Chang CL
• Lee EY
• Son HC

• KMID: 1130036
• DOI: http://doi.org/10.3346/jkms.2003.18.5.669

Abstract

The Di(a) antigen is well known as one of the antigens with low incidence among Caucasians; however, it has been discovered with a relatively higher incidence among Mongoloid populations. Thus, it has been speculated that the incidence of unexpected antibody against the Di(a) antigen might be relatively higher among these populations. Hemolytic transfusion reactions (HTRs) and hemolytic disease of the newborns (HDNs) caused by anti-Di(a) have been reported sporadically. However, there has been no prospective study on the incidence of anti-Di(a) in Mongoloid populations particularly. The authors conducted a series of antibody screening tests on 11,219 Korean individuals for 25 months, by using three kinds of screening cells including Di(a) cell. Anti-Di(a) was detected in 8 patients, seven of whom had a history of transfusions or were multigravida. The incidence of anti-Di(a) measured in this study was higher than expected, ranked third among unexpected antibodies identified during the period of the study, so it is strongly recommended that the Di(a+) panel cell must be incorporated into antibody screening test for safer transfusion in Asian-Mongoloid populations.

Keyword

Di(a) Antigen; Blood Banks; Ethnic Groups; Anti-Di(a); Antibody Screening Test

MeSH Terms

Adult
*Antibody Formation
Asian Continental Ancestry Group
Blood Banks
Blood Group Antigens/*immunology
Blood Grouping and Crossmatching
Blood Transfusion
Erythrocytes/immunology
Female
Human
Immunologic Techniques
Korea
Male
Middle Aged
Support, Non-U.S. Gov't